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Candida albicans is an opportunistic fungal species commonly colonizing human mucosal surfaces. However, when host defenses are weakened, C. albicans can proliferate causing an array of infections ranging from mucosal to systemic infections that are often life-threatening. Oral candidiasis is considered an AIDS defining opportunistic infection with up to 80% of HIV+ individuals suffering recurrent episodes during the course of their HIV disease progression. As a dimorphic microbial species, C. albicans is capable of switching morphology between yeast and hyphal forms. Where the yeast form is responsible for systemic disease, hyphae are invasive filaments and therefore are adept at causing mucosal infections.
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