Magnesium may enhance physical activity through a number of associated mechanisms: all phosphotransfers, a cofactor to over 325 enzymatic reactions, protein synthesis, and electrolyte balance. Magnesium deficiency has not been recognized may be attributed to only 1% of Magnesium is in the serum, therefore, a lack of sensitivity of serum Magnesium. Low dietary intakes, coupled with exercise-induced urinary losses, may eventually lead to Magnesium deficiency. A deficiency of the mineral therefore has many physiological and exercise performance implications.

 

Clinical studies have described Magnesium influence on immune function and inflammation; with low magnesium stimulating immunopathological changes that are related to the initiation of a sequential inflammatory response. Low serum and dietary magnesium levels are strongly correlated with low grade systemic inflammation. Experimental Magnesium deficiency produces a clinical inflammatory syndrome with leukocyte and macrophage activation, inflammatory cytokines released, and excessive production of free radicals. Results from animal studies have been corroborated in human responses, with Magnesium deficiency up regulating markers of inflammation and oxidative stress. Magnesium deficiency elicits a systemic pro-inflammatory/prooxidant state, involving multiple tissues or organs.