Over the last decade, documented research has gained importance in every system, more so in medicine. Homeopathy is no exception, as evident from a sharp increase in the number of researches being published in various homeopathic journals. The question ‘why to research’ has well been overcome by the community taking keen interest in not only carrying out researches, but also sharing those through publications and presentations. However, another question ‘what to research’ is getting more and more relevant for various reasons. One, because even though the numerous researches conducted in homeopathy have taken homeopathy to a higher level, much remains desirable to take it to the level of international acceptance. This calls for a serious analysis of what ‘exactly’ should be the elements on which the research needs to be focused upon, in order to gain maximum acceptance. Two, there are many areas that have been exhaustively researched and researching those further might not be as productive as investing the same amount of time, energy and resources on some other more relevant and vital research area. This is largely true for the clinical researches on various oft-repeated conditions. The paper aims at appraising the homeopaths interested in research about the various challenges lying ahead for homeopathy, the research in which could prove to be more apt and worthwhile for both the researcher and the profession.
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