alexa Effect of Dietary zinc on homocysteine levels and methionine synthase and betaine-homocysteine methyltransferase expression in rats

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Effect of Dietary zinc on homocysteine levels and methionine synthase and betaine-homocysteine methyltransferase expression in rats

Methionine synthase (MS) and betaine-homocysteine methyltransferase (BHMT) are both zinc (Zn)-dependent methyltransferases and involved in the methylation of homocysteine. The objective of this study was to investigate the effects of dietary Zn supply on homocysteine levels and expression of the two enzymes in growing rats. Male weanling Sprague-Dawley rats were assigned randomly to four dietary groups (n = 8/group) for 3 weeks: Zn deficient (ZD; <1 mg Zn/kg); Zn control (ZC; 30 mg Zn/kg); Zn supplemented (ZS; 300 mg Zn/kg); pair fed (PF; 30 mg Zn/kg) to the ZD group.

Courtesy: Jing et al., 2015 [DOI:10.1016/j.jtemb.2014.10.013]

 
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