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Zinc is an essential trace element with wide-ranging biological functions, while the Hedgehog (Hh) signaling pathway plays crucial roles in both development and disease. Here we show that there is a mechanistic link between zinc and Hh signaling. The upstream activator of Hh signaling, the Hh ligand, originates from Hh autoprocessing, which converts the Hh precursor protein to the Hh ligand.
Courtesy: Xie et al., J Biol Chem, 2015 Mar 18
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