alexa Physiology of Airway Smooth Muscle Contraction: An Overview

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Physiology of Airway Smooth Muscle Contraction: An Overview

Bronchial reactivity is a physiological property of healthy airways to develop a moderate airway obstruction in response to various non specific stimuli. The active effector of airway reactivity is airway smooth muscle, located in the wall of the airways, which contraction induces a reduction in airway lumen and hence an increased resistance to air flow. The contractile state of airway smooth muscle (ASM) is modulated by a variety of extracellular agonists acting on specific receptors located in the plasma membrane of ASM cells (ASMCs). Stimulation of these receptors activates a cascade of intracellular events that lead to ASMC contraction or relaxation.

 

Citation: Ouedraogo N, Roux E (2014) Physiology of Airway Smooth Muscle Contraction: An Overview. J Pulm Respir Med 4:221

 
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