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Bronchial reactivity is a physiological property of healthy airways to develop a moderate airway obstruction in response to various non specific stimuli. The active effector of airway reactivity is airway smooth muscle, located in the wall of the airways, which contraction induces a reduction in airway lumen and hence an increased resistance to air flow. The contractile state of airway smooth muscle (ASM) is modulated by a variety of extracellular agonists acting on specific receptors located in the plasma membrane of ASM cells (ASMCs). Stimulation of these receptors activates a cascade of intracellular events that lead to ASMC contraction or relaxation.