alexa Aining Granule Stabilizes the Decline of CD4 Cell Count in HAART

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Aining Granule Stabilizes the Decline of CD4 Cell Count in HAART

China and some developing countries still have vast regions that older regimen of Highly Active Antiretroviral Therapy (HAART) is being administered. According to UNAIDS 2012 China AIDS Response Progress Report, China has a population of 780,000 people living with HIV/AIDS (PLHIV). While HAART is the mainstream medicine in many countries, in China Chinese medicine has also been widely used as auxiliary medicine to ameliorate the side-effects of HAART. Chinese medicine herbal formulas were found to be effective in promoting T lymphocytes either in the early or intermediate stages of HIV infection or advanced AIDS, though the mechanisms remain to be elucidated. Due to social belief, HAART availability and toxicity considerations, Chinese medicine is also used solely by a significant number of PLHIV in China. Previously we reported that combination therapy of HAART and Aining granule had resulted in a slower depletion of CD4 T cells and improvement in signs and symptoms, without any apparent adverse effects. In spite of statistically significant results, we only compared time point to time point but did not take the course into consideration. Moreover, it is not known how the slowdown in CD4 T cell decline is related to the course. Bioinformatics techniques were used to explore patterns in various settings and an in-depth pattern discovery shall shed light for better design of molecular experiments, drug administration and policy making.


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