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Introduction: High sensitivity C-reactive protein (hsCRP) is a reliable biomarker of inflammation. Plasma CRP increases dramatically after severe trauma, bacterial infection and inflammation. The hsCRP accurately and sensitively measures basal levels of CRP, including in the areas of increased risk of developing myocardial infarction. Tobacco smoking has also been indicated to influence pregnancy outcomes and infertility. Methods: We examined the associations between smoking, circulating hsCRP, and steroid hormone levels in healthy, non-pregnant women of reproductive age. Serum hsCRP concentrations were analyzed using immunoturbidimetry. Based on cotinine levels and self-questionnairres, the women were divided into three separate groups of smokers, nonsmokers.