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Hepatitis B virus (HBV) is a serious public health problem worldwide and a major cause of chronic hepatitis, cirrhosis, and hepatocellular carcinoma (HCC). HBV vaccination is the most effective measure for prevention of HBV infection. Published data concerning the long-term immunogenicity of HB vaccine in Egyptian children indicated that the vaccine was effective in preventing HBV infection with an efficacy of more than 90% and that booster doses are unnecessary possibly due to protective anamnestic response to antigenic challeng
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