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Although originally considered merely structural components of cellular membranes, glycosphingolipids (GSL) are now recognized as having critical effects on cellular physiology, including proliferation, differentiation, viral transformation and ontogenesis. In addition, a vast majority of human cancers have modified GSL composition compared to parental normal cells. These modifications may contribute to both tumor survival and exert striking effects on anti-tumor immunity. In this review, we discuss mechanisms of immune modulation by tumor-secreted GSL.
Citation: Lardone RD, Cely I, Sieling PA, Lee DJ (2014) Immune Response Modulation by Tumor-Secreted Glycosphingolipids. J Glycobiol 3:107. doi: 0.4172/2168-958X.1000107
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