Seronegative spondyloartropathies belongs to a group of rheumatic diseases; share certain clinical characteristics, Inflammatory back pain and stiffness are prominent early in the disease, whereas chronic, aggressive disease may produce pain and marked axial immobility or deformity. Some are strongly associated with the HLA-B27 allele. Rheumatoid Factor (RF) is negative in the spondyloartropathies (hence, they are called Seronegative spondyloartropathies). They include ankylosing Spondylitis, reactive arthritis, psoriatic arthritis, and other disorders. Modern medicine has no established treatment for it. From the Ayurveda perspective, the disease can fall under amavata, which may be effectively managed when intervention is started in its early stages Dasamula niruha vasti, combined by Shamana treatment with Brihatvata chintamaniras and Trayodasanga guggulu, Simhanada guggulu, Amavatariras and Dasamularishta have been found effective in curbing its progression. This article presents a single case report in which these treatments achieved considerable success.