Stress and depression is known to have serious impact on your body and skin. There is a field of dermatology called as psychodermatology that deals with the link of skin and psychological aspects. Stress can cause acne, hairfall and even serious skin conditions such as psoriasis. The actual connection relies on role of neuropeptides, hormones, and neurotransmitters released in the body during various stages. Stress activates 2 pathways such as sympathetic nervous system and hypothalamic-pituitary-adrenal axis and thus making some changes in the overall bodily activities. These findlings are validated along with observations such as stress in 44% of patients before the initial flare of psoriasis.