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Juvenile idiopathic arthritis (JIA) is a systemic autoimmune disease of unknown origin, which is characterized by chronic inflammation of the joints similar to RA. It is one of the most common chronic illnesses of childhood. Patients with JIA are divided into seven subgroups, which include oligoarthritis, RF-positive polyarthritis, RF-negative polyarthritis, extended oligoarthritis, systemic arthritis, psoriatic arthritis, and Enthesitis-Related Arthritis (ERA) [1]. The diagnosis of JIA depends primarily on clinical manifestations of the disease.
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