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Histone proteins, which are like spools in which DNA is the thread, are essential for packaging DNA in cells. Histones can be modified in many ways, which affects how the DNA is packaged, and how genes are turned on and off. The H3 modification, named H3K36me3, refers to a chemical mark placed at a specific position on the H3 protein. the researchers profiled a genomewide pattern of the H3 modification, and then profiled the expression of all genes in young and old C. elegans nematodes. They found that when genes wrapped around H3 proteins, if the modification existed at low levels, expression of those genes tended to fluctuate with age. At the same time, the expression of genes that wrapped around high levels of the same modification remained stable with age.
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