alexa JAB1/CSN5: A Multifunctional Protein in Cancer

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JAB1/CSN5: A Multifunctional Protein in Cancer

c-Jun activation domain-binding protein 1 (JAB1) was originally identified as a c-Jun co-activator and subsequently discovered to be a component of the COP9 signalosome (CSN) complex. JAB1, which is also known as CSN5, affects many partner proteins through protein-protein interaction, which leads to protein degradation and transcriptional activation. Thereby, JAB1/CSN5 functions as a multifunctional protein involved in the regulation of cell cycle, signal transduction, and DNA repair. In particular, JAB1/CSN5 plays an essential role in tumorigenesis by degrading tumor suppressor proteins and activating oncogenic transcription factors. JAB1/CSN5 overexpression has been observed in various types of cancer, and it has been multifunctionally involved in cancer progression.


Nishimoto A, Kugimiya N, Hosoyama T, Enoki T, Li TS, et al. (2014) JAB1/CSN5: A Multifunctional Protein in Cancer. J Mol Genet Med 8:099 doi: 10.4172/1747-0862.1000099

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