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Synthetic dyes are a large group of organic compound derived from benzene (C6H6), which consists of six carbon and hydrogen atoms. Synthetic dyes are sometimes referred to as "coal tar†since they manufactured from substance which were in the past only obtained from coal tar. In Africa particularly in Nigeria, there are numbers of natural dye plants which are capable of cultivation, just as we have cultivated dye plants in the United Kingdom. Recent studies have given useful result in of such abundant dye plant use as histological stains for some tissue components. This is considering the huge amount of foreign exchange and processes involved in obtaining suitable synthetic dye for histological purpose, and also their attendance disadvantages. Synthetic dyes are very efficient but their application are limited due to their harzard to human and animal health. This has resulted in the withdrawal of some dyes as their harzards become recognized