The aetiology of colorectal cancer (CRC) is complex, developing through a series of progressive changes defined by clinical and histopathological parameters. In this regard, several reports have been published describing the roles of markers involved in progression and development of CRC. In those investigations the transcription factors HIF-1 and NFκB have emerged as markers of significant clinical interest. HIF-1, which is considered the master regulator of the hypoxic response in normal cells, is composed of a constitutively expressed ÃŸ subunit and a hypoxia-induced α subunit rapidly degraded under normoxic conditions.
Citation: Decastel M, Andrea A, Lubeth M, Deloumeaux J, Smith-ravin J (2014) Inflammatory and Cell Adhesion Protein Markers in Colorectal Cancer in Patients Seen at the Teaching Hospital of Guadeloupe: Role of NF kappaB and P-Selectin. J Cytol Histol 5:276.