The coexistence of systemic lupus erythematosus (SLE) and inflammatory bowel disease (IBD) is rare. This report reviews the English and Japanese literature covering the reported cases of concomitant SLE and IBD. We identified 17 cases of concomitant SLE and Crohn’s disease (CD) and 13 cases of concomitant SLE and ulcerative colitis (UC). We observed that many patients (19/28) developed SLE before IBD. Furthermore, SLE was almost never active at presentation of IBD, and flares of SLE were uncommon after IBD development.

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