The effects of loud noise (80 dB) on neurogenesis in the sub-ventricular zone (SVZ) and the hippocampal sub-granular zone (SGZ) was investigated in vivo in the rat brain using positron emission tomography (PET) with 3’-deoxy-3’- [18F]fluoro-L-thymidine ( [18F]FLT), a marker for thymidine kinase I (TK-1) related to cell proliferation and for neurogenesis in SVZ and SGZ. Methods: Five young Sprague-Dawley rats were exposed to loud noise from two speakers set in front of their cages during the night for 4 nights, and 5 control rats were exposed to normal quiet conditions. PET was performed 4 days after the exposure.
Citation: Zapata-Sudo G, Sudo SZ, Alencar AKN, Sudo RT (2014) Targeting of the Adenosine Receptors as A Novel Strategy for the Treatment of Arterial Hypertension . J Neurol Neurophysiol 5:243 doi: 10.4172/2155-9562.1000243