alexa Contribution of Next Generation Sequencing Technologies

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Contribution of Next Generation Sequencing Technologies

Next generation sequencing (NGS) technologies have directly leaded to the recent advances in epigenome research of stem cell and cancer. DNA methylation and histone modification are two major epigenetic modifications. Four NGS-based approaches have been developed to identify these two epigenetic modifications, including whole genome bisulfite sequencing (WGBS), methylated DNA Immunoprecipitation Sequencing (MeDIP-Seq), reduced representation bisulfite sequencing (RRBS) and chromatin immunoprecipitation sequencing (ChIP-Seq).

 

Citation: Li J, Wang T, Zhang X, Yang X (2011) The Contribution of Next Generation Sequencing Technologies to Epigenome Research of Stem Cell and Tumorigenesis . Human Genet Embryol S2:001.

 
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