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Embryonic stem (ES) cells are used in various fields for diverse purposes, including gene targeting, cell therapy, tissue repair, organ regeneration, and so on. However, studies on and applications of ES cells are hindered by ethical disputes regarding cell source. To circumvent ethical issues, scientists have attempted to generate ES celllike cells, which are not derived from the inner cell mass of blastocyst-stage embryos. In 2006, Yamanaka first reprogrammed mouse embryonic fibroblasts into ES cell-like cells, which were called induced pluripotent stem (iPS) cells.
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