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Irritable bowel syndrome (IBS) constitutes approximately 50% of a gastroenterologist’s practice and amongst the most common gastrointestinal disorders [1]. Diarrhea predominant IBS is thirty percent (30%) of that number and involves twelve percent (12%) of people across five continents with significant social, emotional and economic impact [2]. Hence, addressing this entity and understanding the pathogenesis and therapeutic options is of utmost importance. Chronic Diarrhea is defined as greater than three bowel movements per day for at least three months. This symptom may vary from simple urgency and frequent bowel movements to incontinence resulting in tendency to locate the closest bathroom to avoid embarrassment, “bathroom mapping”. This imposes significant emotional stress on the suffering subject and frequently results in social embarrassment. What technically separates functional diarrhea from IBS-D is the satisfaction of special criteria created to define this exact entity. The latest of which is Rome III criteria in which discomfort and/or pain is used as a mainstay of the criteria together with altered bowel habits
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