Human Follicle-Stimulating Hormone (FSH) is a heterodimeric member of the glycoprotein hormone subfamily of the cystine knot growth factor superfamily . FSH consists of a common subunit that it shares with three other glycoprotein hormones, Luteinizing Hormone (LH), Chorionic Gonadotropin (CG), and Thyroid- Stimulating Hormone (TSH). A non-covalently associated FSHβ subunit confers hormone specificity. Both subunits possess two potential N-glycosylation sites. While the FSHα subunit exhibits only microheterogeneity in its glycosylation, the FSHβ subunit exhibits both macro- and micro-heterogeneity.
Citation: Bousfield GR, Butnev VY, White WK, Hall AS, Harvey DJ (2015) Comparison of Follicle-Stimulating Hormone Glycosylation Microheterogenity by Quantitative Negative Mode Nano-Electrospray Mass Spectrometry of Peptide-N-Glycanase-Released Oligosaccharides. J Glycomics Lipidomics 4:129.