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Human Follicle-Stimulating Hormone (FSH) is a heterodimeric member of the glycoprotein hormone subfamily of the cystine knot growth factor superfamily . FSH consists of a common subunit that it shares with three other glycoprotein hormones, Luteinizing Hormone (LH), Chorionic Gonadotropin (CG), and Thyroid- Stimulating Hormone (TSH). A non-covalently associated FSHβ subunit confers hormone specificity. Both subunits possess two potential N-glycosylation sites. While the FSHα subunit exhibits only microheterogeneity in its glycosylation, the FSHβ subunit exhibits both macro- and micro-heterogeneity.
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