The sequencing of the human genome and related organisms represents one of the most significant and historic scientific accomplishments. The process of determining the sequence of DNA, proposed by Sanger , has led to the sequencing of the entire genome of an organism. The first finished genome to be published was of the Haemophilus influenza . Within three years of this groundbreaking publication, more than 10 other genomes of model bacterial species like Escherichia coli and Bacillus subtilis and pathogens, such as Helicobacter pyroli and Mycobacterium tuberculosis were published. The Institute of Genomic Research (TIGR) was a substantial leader in the genomic field by fully sequencing the genome of the yeast. It was a tremendous effort, utilizing 600 scientists from over 100 laboratories and representing the largest decentralized experiment in modern molecular biology.