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The purpose of this randomized control trial was to determine whether choline in combination with several doses of caffeine, could facilitate short-term visual and verbal memory and attention in adult and middle aged human subjects with normal cognitive function. The effects of several doses of caffeine in combination with choline on short-term visual and verbal memory, blood pressure and heart rate were assessed in 125 healthy adult and middle-aged men and women using six standardized tests from the Wide Range Assessment of Memory and Learning, Second Edition (WRAML 2).