Objectives: Phytoestrogens exert variety of actions involving many target tissues. The effects of dietary phytoestrogens, as hormonal replacement therapy (HRT), on the level of estradiol receptor alpha (ERα), estradiol receptor beta (ERβ) and vascular endothelial growth factor (VEGF) in uterine tissues of ovariectomized female rats were studied. Methods: Twenty mature ovariectomized female albino rats weighed (130-150 gm) were divided into two groups (G1) control group (n=10) fed on a casein based ration (phytoestrogen free) and (G2) treated group (n=10) received high phytoestrogen diet. Daily food intake (FI) and body weight gain (BWG) were recorded. After 30 days of treatment all rats were sacrificed and relative uterine weight for each female was recorded. Histological and immunohistochemical studies for ERα, ERβ and VEGF expression were performed on uteri for both groups.