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The use of herbal supplements as a form of therapeutic intervention or a means to alleviate specific symptoms or drug side effects has continued to increase for both adults and children. This is due in part to their immediate and broad availability as well as the misconception of the universal safety of natural products. Because the active components in herbal supplements use the same metabolic and transport proteins as prescription medications there is an increase in the likelihood of an unfavorable interaction when taken concomitantly. While there has been a significant amount of in-vitro research into drug–herbal inhibition, the majority of it has been with individual compounds from various herbals which do not necessarily mimic what may occur in-vivo when dosed with the entire herbal preparation. In our laboratory we focus on the cumulative drug-herbal effect of both the commercially available herbal product as it would taken by a patient as well as individual components of these herbals.
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