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Medicinal chemists design, discover and develop small molecule drugs for various drug targets and diseases. Recent advances in understanding disease development and new technologies such as high throughput screening (HTS), computer-aided drug design (CADD), combinatorial chemistry and microwave synthesis have markedly facilitated the drug design and discovery process. The idea of creating new drugs is now moving from serendipity to rational design. Discovery of new drugs is carried out mainly by using processes, (1) screening of natural or synthetic compounds finding activity in a variety of biological screens, and (2) targeted approach which is characterized by a more rational approach, in which knowledge about specific enzymes and/or receptors are used as targets.
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