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Histologically, bladder cancer originates from the transitional epithelium that is composed of 3 to 6 layers of basal, intermediate, and multinucleate umbrella cells. So, there are three types of bladder cancer namely: transitional cell carcinomas, which account for more than 90% of bladder tumors; squamous cell carcinomas, which constitute about 8% of bladder tumors and are usually associated with long-term infection or irritation of the urothelium in addition to adenocarcinomas, which account for about 2% of bladder neoplasms and arise from the glandular (secretory) cells and often have urachal or metaplastic origin
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