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When it is damaged immune and accessory cells go through and reach the brain, which is an immunological privileged organ, and after that these immunological components infiltrate the extracellular compartments and cause neuronal damage and neurotoxicity. Autoantibodies with specificity for neuron cells and other components of the central nervous system react with their targets, causing for example, demyelination as it is seen in several neurological diseases including multiple sclerosis, neuromyelitis optica, Guillain-Barré syndrome and chronic inflammatory demyelinating polyneuropathy that are autoimmune diseases, where the damaged myelin impairs the conduction of signals in the affected nerves.
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