The universe of computational and theoretical chemistry is rich, vast, and growing exponentially. The major impetus behind this extraordinary growth curve in recent decades has undoubtedly been the profusion of scientific and technological breakthroughs. Arbitrarily choosing my lifetime (1950-) as a yardstick, we have witnessed an almost endless progression of amazing scientific discoveries and technological achievements: the discovery of DNA’s structure and, thereupon, the birth of molecular genetics in the 1950s; the Space Age in the 1960s and 70s; the Digital Age and rise of the personal computer in the 1980s; the emergence of the supercomputer, the Internet, and the World Wide Web in the 1990s; the outgrowth of genomics and bioinformatics from the Human Genome Project in the 2000s; to the Information Age (Informatics) today. Individually and together, these scientific and technological advances, and many others omitted here for the sake of brevity, have forever transformed the landscape of theoretical and computational science. We have every reason to expect that the procession of scientific and technological discoveries, inventions, and innovations will continue into the future. In each of these developments, theoretical and computational science has played the role of both benefactor and beneficiary.