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Catechol-bearing block copolymer micelles: Structural characterization and antioxidant activity

Oxidative stress caused by uncontrolled production of reactive oxygen species (ROS) has been linked to the initiation and progression of some diseases. Therefore, the use of antioxidants capable of scavenging ROS has attracted growing interest. We recently reported antioxidant micelles having catechol moieties, a structural motif found among natural antioxidants. These micelles showed a strong inhibitory effect in ROS-mediated angiogenesis as compared to the small catecholic compound dopamine. Here, we aim to explain this interesting function of the micelles by correlating the effects of self-assembled structures on the auto-oxidation stability and anti-angiogenic activity.

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