alexa Biomimetic Calcium Phosphate Coatings for Polymeric Artificial Spinal Disc Implants

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Biomimetic Calcium Phosphate Coatings for Polymeric Artificial Spinal Disc Implants

Discs of poly carbonate urethane (PCU) werecoated with a thin layer of calcium phosphate (CaP) bya biomimetic process at temperatures of 28◦C and 37◦C.The coating morphology was analyzed by SEM. Contactangle analysis was used to assesssurface wettability.Human osteoblasts (HOBs) were cultured on uncoatedand CaP-coated PCU discs for up to 14 days. Cellmetabolism, structure, and morphology were analyzedand compared with the wettability of each sample group. HOBs proliferated and grew on uncoated and CaP-coatedsamples, but a greater cell metabolism was observed foruncoated samples at early time points in cell culture. A more even dispersion of HOBs across the disc surface, attributable to the increased surface wettability, was seenfor CaP-coated samples.
 
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