Cinnamoum reticulatum Hayata (Lauraceae) is an indigenous tree species in Taiwan. In this study, we further isolated the two flavonoids compounds kaempferol-3-O-(2",4"-di-E-p-coumaroyl)-α-L-rhamnopyranoside (1) and kaempferol-3-O-(3",4"-di-E-p-coumaroyl)-α-L-rhamnopyranoside (2) from the leaves and stems of C. reticulatum Hayate. The phytochemical characteristics, antioxidant and cytotoxic activities of the two compounds were evaluated. Kaempferol-3-O-(2",4"-di-E-p-coumaroyl)-α-L-rhamnopyranoside (1) and kaempferol-3-O-(3",4"-di-E-p-coumaroyl)-α- L-rhamnopyranoside (2) have antiproliferation activity in lung cancer cell line (A549 and NCI-H460) and breast cancer cell line (MCF-7 and MDA-MB-231). However, (1) displays better antioxidant activity than (2). Our results showed that the two flavonoids from C. reticulatum might have good potential for further development as chemoprevention or antioxidant remedies.
Citation: Liu CM, Yeh HC, Huang SC, Li CT, Chen CY (2015) The Antioxidation and Antiproliferation Activity of New Flavonoids from the Leaves and Stems of Cinnamomum reticulatum Hayate. Med chem 5: 064-066. doi: 10.4172/2161-0444.1000244