alexa The Antioxidation and Antiproliferation Activity of New Flavonoids from the Leaves and Stems of Cinnamomum reticulatum Hayate

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The Antioxidation and Antiproliferation Activity of New Flavonoids from the Leaves and Stems of Cinnamomum reticulatum Hayate

Cinnamoum reticulatum Hayata (Lauraceae) is an indigenous tree species in Taiwan. In this study, we further isolated the two flavonoids compounds kaempferol-3-O-(2",4"-di-E-p-coumaroyl)-α-L-rhamnopyranoside (1) and kaempferol-3-O-(3",4"-di-E-p-coumaroyl)-α-L-rhamnopyranoside (2) from the leaves and stems of C. reticulatum Hayate. The phytochemical characteristics, antioxidant and cytotoxic activities of the two compounds were evaluated. Kaempferol-3-O-(2",4"-di-E-p-coumaroyl)-α-L-rhamnopyranoside (1) and kaempferol-3-O-(3",4"-di-E-p-coumaroyl)-α- L-rhamnopyranoside (2) have antiproliferation activity in lung cancer cell line (A549 and NCI-H460) and breast cancer cell line (MCF-7 and MDA-MB-231). However, (1) displays better antioxidant activity than (2). Our results showed that the two flavonoids from C. reticulatum might have good potential for further development as chemoprevention or antioxidant remedies.

Citation: Liu CM, Yeh HC, Huang SC, Li CT, Chen CY (2015) The Antioxidation and Antiproliferation Activity of New Flavonoids from the Leaves and Stems of Cinnamomum reticulatum Hayate. Med chem 5: 064-066. doi: 10.4172/2161-0444.1000244

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