alexa Distinct Circuits Underlie the Effects of 5-HT1B Receptors on Aggression and Impulsivity

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Distinct Circuits Underlie the Effects of 5-HT1B Receptors on Aggression and Impulsivity

Impulsive and aggressive behaviors are both modulated by serotonergic signaling, specifically through the serotonin 1B receptor (5-HT1BR). 5-HT1BR knockout mice show increased aggression and impulsivity, and 5-HT1BR polymorphisms are associated with aggression and drug addiction in humans. To dissect the mechanisms by which the 5-HT1BR affects these phenotypes, we developed a mouse model to spatially and temporally regulate 5-HT1BR expression.

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