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Crohn’s disease also known as crohn’s syndrome is said to be an type IV hypersensitivity immune response. It is a type of inflammatory bowel’s disease where the affected area covers the entire gastrointestinal track from mouth to rectum. The exact cause’s of this disease is an topic of debate but presently prevailing hypothesis relate it innate immunity impairment where the macrophages are said to secrete improperly folded domains of the cytokines. Environmental factors are also held responsible directly as in to carriage of microorganisms into the gastrointestinal track or indirectly as to in mutation of either gut microorganisms or of macrophages.
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