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Discoid lupus erythematosus (DLE) is a chronic skin condition that causes sores with inflammation and scars over the face, ears, and scalp and at times on other body areas. It is one among many other types of lupus erythematosus. These lesions develop as a red, inflamed patch with a scaling and crusty appearance. The center areas may appear lighter in color with a rim darker than the normal skin. It is usually said to be influenced by gene polymorphisms, 30 of which have now been linked with the disorder. Some of these polymorphisms have been linked very tentatively however, as the role that they play or the degree to which they influence the disease is unknown. Other genes that are commonly thought to be associated with Lupus are those in the Human leukocyte antigen (HLA) family, which are largely related to healthy functioning of the immune system.
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