The observable trend in the concept of evolution creates a template that advanced cell types are evolved from rudimentary cells over time. This is evident in protein structure and function observed along the evolutionary trend. An important component of cell evolution involves the role of microtubules and other members of the conserved family of the cell cycle/division proteins that have shown consistency from the yeast to the Homo sapiens over a billion years. In this study, we used specific imaging technique to compare the structure of melanocytes by manipulating NMDA R and VDR; to foster the study of synaptic denervation and pigment loss observed in PD. This information is important, as careful analysis and guided extrapolation of data can yield results of transnational significance. The outcome from two separate studies shows that both NMDA R and VDR are involved in cellular process formation in a way that can be likened to adrenergic cell process formation. Thus suggesting a possibility of adopting this cell type as a model.