A dominant contributor to the development of both diseases that affect a structure in the kidney known as the glomerulus (glomerular diseases) and kidney failure is injury and loss of kidney cells known as podocytes. New research performed by the scientist has now determined that podocyte integrity in mice is maintained by the cellular process autophagy. In the study, mouse podocytes were found to naturally undergo high levels of autophagy. Moreover, crossing out of the gene autophagy-related 5 in podocytes led to podocyte loss and glomerular disease in aging mice and to increased susceptibility to models of glomerular disease in young mice. The researchers therefore suggest that autophagy helps protect against podocyte aging and glomerular injury and that it could be targeted to reduce human glomerular disease and aging-related loss of kidney function.