Avascular Necrosis, also called as Osteo Necrosis is a common bone disease that has been observed to avail in the patients with Systemic Lupus Erythematosus and Antiphospholipid Syndrome. In this disease, the bone tissues die due to insufficient supply of blood to the bones. This may occur due to dislocation of bones or a fracture. In this disease, the bones are broken leading to ultimately a bone replacement surgery. This generally occurs in longer bones like femoral and humeral bones. SLE can also get associated to other musculoskeletal diseases like neuro-muscular disorders. One such example is spinal muscular atrophy.