Systemic Lupus Erythematosus is mainly diagnosed traditionally. The presence of anti double stranded DNA and hypo-complement in the blood serum is used to analyze the presence of systemic lupus in the human body. They are analyzed with their quantity which helps the doctors to find the level of autoimmunity raised inside an individual’s body. However, Now-a day, the researchers have found this method a bit in efficient. According to the paper Li and Zhang, Complement System plays a major role in the procedure of analysis and diagnosis of SLE in the body. Complement activation leads to the production of several complement products. Complement Activation product CD4 produced after the activation of CD complement has been seen to act as a biomarker in an autoimmune diseased body.