Multiple sclerosis (MS) is the most common cause of acquired neurologic disability in young adults. In 70% of cases, symptoms first emerge between the ages of 20 and 40 years. The exact cause is not known, but current theories suggest that MS is an inflammatory autoimmune disorder. As the patient with MS ages, the morbidities and physiologic changes associated with the normal aging process have an effect on the severity of impairment and disability. Aging with Multiple Sclerosis disease of aging such as stroke, cancer, heart disease, diabetes, and patients also need to be evaluated and treated for these conditions.