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Sleep disorders are common in multiple sclerosis (MS), including insomnia, sleep apnea, restless legs syndrome (RLS), narcolepsy, and rapid eye movement (REM)-sleep behavior disorder (RBD) are also seen. About 40% of patients with MS have insomnia; causes include pain related with muscle spasms, periodic limb movements, RLS, nocturia, medication effect, and depression. Demyelinating lesions in the medullary reticular formation could have an effect on nocturnal respiratory effort, leading to sleep-disordered breathing. However, the prevalence of nocturnal respiratory disturbances in MS is relatively low.
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