High-volume local infiltration analgesia is effective in knee arthroplasty, but the analgesic efficacy of systematic infiltration with high-volume local anesthetic in major lumbar spine surgery in L3 to S1 has not been clarified. A trial to evaluate the analgesic efficacy of intraoperative Local Infiltration Analgesia (LIA) administration and postoperatively via injections through intraoperatively placed wound catheters. In a randomized, double-blind, placebo-controlled trial in 48 patients undergoing major lumbar spine fusion surgery, 70 mL saline (n=24) or ropivacaine 0.5% with adrenaline (n=24) was infiltrated using a systematic technique to all tissue incised, handled or instrumented during surgery and with repeated injections at 6, 12 and 24 h postoperatively with 10, 10 and 20 mL. Twenty-two patients in each group were used for analysis.
Citation: Kristensen BB, Karacan H, Agerlin M, Nimb L, Stentoft J, et al. (2014) High-Volume Infiltration Analgesia in Major Lumbar Spine Surgery. A Randomized, Placebo-Controlled, Double-Blind Trial. J Anesth Clin Res 5:450.