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Ameloblastomas are benign, locally invasive odontogenic tumors of epithelial origin, which are derived from the tooth-forming apparatus. They account for approximately 60% of odontogenic tumors of the mandible and 10% of all jaw tumors.The case was 20 years old man with slow growing mass from three years ago. CT scan showed huge heterogeneous mass with right side mandibular destruction. After diagnosis, right side mandibular resection with reconstruction was done.