For decades HeLa cells have provided effective and easily usable biological models for researching human biology and disease. They are widely regarded as the industry standard tool for studying human biology which led to host of advancements in many areas, including cancer, development of the polio vaccine and HIV/AIDS. Researchers successfully sequenced the genome of a HeLa cell line, which had never been donebefore.
The modern molecular genetic studies using HeLa cells are typically designed and analyzed using the Human Genome Project reference. These cells are most commonly used human cell lines, and helped in understanding many fundamental biological processes, which provides a high-resolution genomic reference that reveals the striking differences between the HeLa genome and normal human cells.
Researchers analyzed HeLa genome which revealedfactorsassociatedcells like losing healthy genes, as well as widespread abnormalities in both the number and structure of chromosomes. The countless regions of the chromosomes in each cell were arranged in the wrong order and had extra or fewer copies of genes.This is chromosome shatteringsign, which is anewly discovered phenomenon associated with 2-3% of all cancers. The genetic landscape knowledge of these cells can inform the design of future studies utilizingHeLa cells, and supports the biological conclusions that can be made from them.
The research outcomes provide the first detailed sequence of a HeLagenome;it demonstrates how genetically complex HeLa is compared to normal human tissue. Even though the possibly because of this conditions, none and successfully and systematicallysequenced the genome, until now. This study gains the importance of accounting for the abnormal characteristics of HeLa cells in experimental design and analysis, which has the potential to refine the use of HeLa cells as a model of human biology.
For more details: https://www.omicsonline.org/biology-and-medicine.php