Objective: To evaluate the weight of debris and irrigant volume extruded apically from root canals using the Revo-S system compared to that of ProTaper and HERO Shaper systems. Methods: Sixty single rooted teeth were selected and randomly divided into three groups. Each group was assigned to one of the three instrumentation systems: ProTaper, HERO Shaper and Revo-S system. The canals were irrigated with a total of 6 ml of distilled water using a conventional needle. Apically extruded debris and irrigant were collected and measured. Results: The mean and the standard deviation values of dry debris weight with ProTaper system, HERO Shaper system and the Revo-S system were 1.71 ± 0.11 mg, 1.63 ± 0.12 mg and 1.56 ± 0.08 mg respectively and the mean irrigant volume and the standard deviation values were 17.5 ± 2.4 ml, 15.8 ± 1.8 ml and 14.4 ± 3.1 ml respectively. The differences between the three groups were not statistically significant (P > .05). Conclusion: The Revo-S system was comparable to the ProTaper and HERO shaper systems in terms of apically extruded debris and irrigant.