Despite efforts of individual clinicians and institutions to prevent continuing deficiencies in children health care quality; manifold gaps and disparities exist. Refining global standards for child health research compels using Standards for Research (StaR) Child Health program, which addresses the contemporary scarcity of and deficiencies in pediatric clinical trials. StaR Child Health brings together leading international experts devoted to developing practical, evidence-based standards to enrich the reliability and relevance of pediatric clinical research. The priority issues concerned are consent and recruitment, containing risk of bias, data monitoring committees, determining adequate sample size, selection, measurement, and reporting of outcomes, age groups for pediatric trials, complex interventions, rare diseases' trials and appropriate comparators. The currently much needed research in children's health may improve if the guidelines developed through StaR Child Health are implemented in practice. So far, representatives of a variety of stakeholder groups, including clinicians, researchers, methodologists, industry partners, regulators, and journal editors participate in various activities of StaR Child Health.