Purpose: We analyzed the polysomnographic (PSG) profile and various factors contributing to sleep disturbances in patients with GB Syndrome. Methodology: This prospective hospital based study included 30 adults with GB syndrome (mean: 34.30 ± 1.40 years; M:F=24:6). All patients underwent evaluation with phenotypic details, nerve conduction studies, sleep questionnaires and over-night polysomnography (PSG). Three (10%) patients had baseline sleep disturbances with a Pittsburgh Sleep Quality Index (PSQI) of >5 and all the 3 patients continued to have poor sleep during hospitalization. Sixteen (53.3%) patients had poor sleep during their hospital stay as assessed by Richards score. Sleep disturbances as per St Mary’s sleep score depicted similar observations over 10 nights. Overnight PSG was carried out within 1st to 12 day of hospitalization (mean: 6.83 ± 3.07; median: 6.5).