Cat cause allergies when the skin comes in contact with proteins in the cat's saliva, urine, and dander. People with allergies have oversensitive immune systems. Their bodies mistake harmless things -- like cat dander -- for dangerous invaders, and attack them as they would bacteria or viruses. Outside cats can bring in pollen, mold, and other allergens on their fur. Allergic reaction to cats include swollen, red, itchy, and watery eyes; nasal congestion, itchy nose, sneezing, chronic sore throat or itchy throat, coughing, wheezing, asthma, hay fever, hives or rash on the face or chest, or itchy skin.